University of California San Francisco

Tara Sigdel, PhD

Tara Sigdel
Tara
Sigdel
PhD

Associate Professor of Surgery
Division of Transplant Surgery

Address

513 Parnassus Avenue HSE, #525E
San Francisco, CA 94143
United States

Email: [email protected]

ORCID: 0000-0001-8448-0328

Biography

My research is driven by two major factors. First, there is an unprecedented pressure to deliver new and improved diagnostic and treatment options to patients. Second, due to improved understanding of biological intricacies with ever improving molecular assays have placed us in a much better position to look for disease specific biomarkers that once validated can be used in the clinics in order to provide timely and accurate assessment of health status of patients.

Education

Education

B.Sc. (Biology and Chemistry) Tribhuvan University, Kathmandu, Nepal

M.Sc. (Chemistry) Tribhuvan University, Kathmandu, Nepal, Advisor: Prof. Vishwanath Pd. Agrawal, PhD

Ph.D. (Biochemistry), Miami University, Oxford, OH, Advisor: Prof. Michael Crowder, PhD

 

Residencies

N/A

 

Awards & Honors

Award Conferred By Date
Pediatric Research Fund – CHRP Award Stanford University, Stanford, CA 2009/2010
Pediatric Research Fund – CHRP Award Stanford University, Stanford, CA 2008/2009
Deans Postdoctoral Fellowship Stanford University, Stanford, CA 2007/2008
Doctoral-Undergraduate Opportunities in Scholarship (DUOS) award for two consecutive years (2003 and Miami University, Oxford, OH 2003/2005
William Hale Charch Graduate Fellowship Miami University, Oxford, OH 2002/2003

Research Narrative

Dr. Sigdel's research is driven by two major factors. First, there is an unprecedented pressure to deliver new and improved diagnostic and treatment options to patients. Second, due to improved understanding of biological intricacies with ever improving molecular assays have placed us in a much better position to look for disease specific biomarkers that once validated can be used in the clinics in order to provide timely and accurate assessment of health status of patients.

Research Interests

Biomarker DIscovery

Proteomics

Immunology

Organ Transplantation

Liver Cancer

Kidney Transplantation

High Throughput Data

Bioinformatics

 

Research Pathways

Basic Biomedical & Translational Research

Publications

MOST RECENT PUBLICATIONS FROM A TOTAL OF 105
  1. Non-HLA antibody trajectories may predict kidney transplant outcomes.
    Rajalingam R, Sigdel TK, Maruthamuthu S, Raghav PK, Laszik ZG, Da Gente G, Kong D, Shoji J, Ray B| | PubMed
  2. HLA and non-HLA antibody profiling in the urine of kidney transplant recipients.
    Sigdel TK, Sarwal MM| | PubMed
  3. Long-term culture of human pancreatic islets reveals reduced metal ion pathways in their gene signature.
    Kato H, Sigdel TK, Sheta M, Omori K, Qi M, Kandeel F, Komatsu H| | PubMed
  4. Novel mechanism for tubular injury in nephropathic cystinosis.
    Sur S, Kerwin M, Pineda S, Sansanwal P, Sigdel TK, Sirota M, Sarwal MM| | PubMed
  5. Cytotoxic KLRG1+ IL-7R- effector CD8+ T cells distinguish kidney transplant recipients controlling cytomegalovirus reactivation.
    Sun Y, Sen S, Parmar R, Arakawa-Hoyt J, Cappelletti M, Rossetti M, Gjertson DW, Sigdel TK, Sarwal MM, Schaenman JM, Bunnapradist S, Lanier LL, Pickering H, Reed EF| | PubMed
  6. Nepal Family Cohort study: a study protocol.
    Kurmi OP, Chaudhary N, Delanerolle G, Bolton CE, Pant PR, Regmi PR, Gautam S, Satia I, Simkhada P, Kyrou I, Sigdel TK, Hundley V, Dali PR, Løkke A, Lam KBH, Bennett D, Custovic A, van Teijlingen E, Gill P, Randeva H, O'Byrne P, Nepal Family Cohort Collaborators| | PubMed
  7. Gene expression-based molecular scoring of pancreas transplant rejection for a quantitative assessment of rejection severity and resistance to treatment.
    Brown AE, Kelly YM, Zarinsefat A, Meier RPH, Worner G, Tavakol M, Sarwal MM, Laszik ZG, Stock PG, Sigdel TK| | PubMed
  8. Proteome Analysis for Inflammation Related to Acute and Convalescent Infection.
    Sigdel TK, Sur S, Boada P, McDermott SM, Arlehamn CSL, Murray KO, Bockenstedt LK, Kerwin M, Reed EF, Harris E, Stuart K, Peters B, Sesma A, Montgomery RR, Sarwal MM| | PubMed
  9. Transcriptional and spatial profiling of the kidney allograft unravels a central role for FcyRIII+ innate immune cells in rejection.
    Lamarthée B, Callemeyn J, Van Herck Y, Antoranz A, Anglicheau D, Boada P, Becker JU, Debyser T, De Smet F, De Vusser K, Eloudzeri M, Franken A, Gwinner W, Koshy P, Kuypers D, Lambrechts D, Marquet P, Mathias V, Rabant M, Sarwal MM, Senev A, Sigdel TK, Sprangers B, Thaunat O, Tinel C, Van Brussel T, Van Craenenbroeck A, Van Loon E, Vaulet T, Bosisio F, Naesens M| | PubMed
  10. Plasma proteome perturbation for CMV DNAemia in kidney transplantation.
    Sigdel TK, Boada P, Kerwin M, Rashmi P, Gjertson D, Rossetti M, Sur S, Munar D, Cimino J, Ahn R, Pickering H, Sen S, Parmar R, Fatou B, Steen H, Schaenman J, Bunnapradist S, Reed EF, Sarwal MM, CMV Systems Immunobiology Group| | PubMed
  11. Perturbations in podocyte transcriptome and biological pathways induced by FSGS associated circulating factors.
    Rashmi P, Sigdel TK, Rychkov D, Damm I, Da Silva AA, Vincenti F, Lourenco AL, Craik CS, Reiser J, Sarwal MM| | PubMed
  12. Longitudinal serum proteomics analyses identify unique and overlapping host response pathways in Lyme disease and West Nile virus infection.
    Boada P, Fatou B, Belperron AA, Sigdel TK, Smolen KK, Wurie Z, Levy O, Ronca SE, Murray KO, Liberto JM, Rashmi P, Kerwin M, Montgomery RR, Bockenstedt LK, Steen H, Sarwal MM| | PubMed
  13. Perturbations of the T-cell immune repertoire in kidney transplant rejection.
    Sigdel TK, Fields PA, Liberto J, Damm I, Kerwin M, Hood J, Towfighi P, Sirota M, Robins HS, Sarwal MM| | PubMed
  14. A reference tissue atlas for the human kidney.
    Hansen J, Sealfon R, Menon R, Eadon MT, Lake BB, Steck B, Anjani K, Parikh S, Sigdel TK, Zhang G, Velickovic D, Barwinska D, Alexandrov T, Dobi D, Rashmi P, Otto EA, Rivera M, Rose MP, Anderton CR, Shapiro JP, Pamreddy A, Winfree S, Xiong Y, He Y, de Boer IH, Hodgin JB, Barisoni L, Naik AS, Sharma K, Sarwal MM, Zhang K, Himmelfarb J, Rovin B, El-Achkar TM, Laszik Z, He JC, Dagher PC, Valerius MT, Jain S, Satlin LM, Troyanskaya OG, Kretzler M, Iyengar R, Azeloglu EU, Kidney Precision Medicine Project| | PubMed
  15. Mass cytometry reveals single-cell kinetics of cytotoxic lymphocyte evolution in CMV-infected renal transplant patients.
    Ishiyama K, Arakawa-Hoyt J, Aguilar OA, Damm I, Towfighi P, Sigdel T, Tamaki S, Babdor J, Spitzer MH, Reed EF, Sarwal MM, Lanier LL, CMV Systems Immunobiology Group| | PubMed
  16. Multiplexed droplet single-cell sequencing (Mux-Seq) of normal and transplant kidney.
    Rashmi P, Sur S, Sigdel TK, Boada P, Schroeder AW, Damm I, Kretzler M, Hodgin J, Hartoularos G, Jimmie Ye C, Sarwal MM, Kidney Precision Medicine Project| | PubMed
  17. FcER1: A Novel Molecule Implicated in the Progression of Human Diabetic Kidney Disease.
    Sur S, Nguyen M, Boada P, Sigdel TK, Sollinger H, Sarwal MM| | PubMed
  18. A Comprehensive Urine Proteome Database Generated From Patients With Various Renal Conditions and Prostate Cancer.
    Swensen AC, He J, Fang AC, Ye Y, Nicora CD, Shi T, Liu AY, Sigdel TK, Sarwal MM, Qian WJ| | PubMed
  19. Use of the Tissue Common Rejection Module Score in Kidney Transplant as an Objective Measure of Allograft Inflammation.
    Zarinsefat A, Guerra JMA, Sigdel T, Damm I, Sarwal R, Chan-On C, Szabo G, Aguilar-Frasco JL, Ixtlapale-Carmona X, Salinas-Ramos C, Ramirez-Martinez L, Ramirez C, Vilatoba M, Morales Buenrostro LE, Alberu JM, Sarwal MM| | PubMed
  20. Corrigendum: Near-Single-Cell Proteomics Profiling of the Proximal Tubular and Glomerulus of the Normal Human Kidney.
    Sigdel TK, Piehowski PD, Roy S, Liberto J, Hansen JR, Swensen AC, Zhao R, Zhu Y, Rashmi P, Schroeder A, Damm I, Sur S, Luo J, Yang Y, Qian WJ, Sarwal MM| | PubMed
  21. A multimodal and integrated approach to interrogate human kidney biopsies with rigor and reproducibility: guidelines from the Kidney Precision Medicine Project.
    El-Achkar TM, Eadon MT, Menon R, Lake BB, Sigdel TK, Alexandrov T, Parikh S, Zhang G, Dobi D, Dunn KW, Otto EA, Anderton CR, Carson JM, Luo J, Park C, Hamidi H, Zhou J, Hoover P, Schroeder A, Joanes M, Azeloglu EU, Sealfon R, Winfree S, Steck B, He Y, D'Agati V, Iyengar R, Troyanskaya OG, Barisoni L, Gaut J, Zhang K, Laszik Z, Rovin BH, Dagher PC, Sharma K, Sarwal MM, Hodgin JB, Alpers CE, Kretzler M, Jain S| | PubMed
  22. Near-Single-Cell Proteomics Profiling of the Proximal Tubular and Glomerulus of the Normal Human Kidney.
    Sigdel TK, Piehowski PD, Roy S, Liberto J, Hansen JR, Swensen AC, Zhao R, Zhu Y, Rashmi P, Schroeder A, Damm I, Sur S, Luo J, Yang Y, Qian WJ, Sarwal MM, Kidney Precision Medicine Project (KPMP) Consortium| | PubMed
  23. Peripheral Blood RNA Sequencing Unravels a Differential Signature of Coding and Noncoding Genes by Types of Kidney Allograft Rejection.
    Pineda S, Sur S, Sigdel T, Nguyen M, Crespo E, Torija A, Meneghini M, Gomà M, Sirota M, Bestard O, Sarwal MM| | PubMed
  24. Targeted Urine Metabolomics for Monitoring Renal Allograft Injury and Immunosuppression in Pediatric Patients.
    Sigdel TK, Schroeder AW, Yang JYC, Sarwal RD, Liberto JM, Sarwal MM| | PubMed
  25. Avoidance of CNI and steroids using belatacept-Results of the Clinical Trials in Organ Transplantation 16 trial.
    Mannon RB, Armstrong B, Stock PG, Mehta AK, Farris AB, Watson N, Morrison Y, Sarwal M, Sigdel T, Bridges N, Robien M, Newell KA, Larsen CP| | PubMed
  26. A urine score for noninvasive accurate diagnosis and prediction of kidney transplant rejection.
    Yang JYC, Sarwal RD, Sigdel TK, Damm I, Rosenbaum B, Liberto JM, Chan-On C, Arreola-Guerra JM, Alberu J, Vincenti F, Sarwal MM| | PubMed
  27. Assessment of 19 Genes and Validation of CRM Gene Panel for Quantitative Transcriptional Analysis of Molecular Rejection and Inflammation in Archival Kidney Transplant Biopsies.
    Sigdel T, Nguyen M, Liberto J, Dobi D, Junger H, Vincenti F, Laszik Z, Sarwal MM| | PubMed
  28. A urinary Common Rejection Module (uCRM) score for non-invasive kidney transplant monitoring.
    Sigdel TK, Yang JYC, Bestard O, Schroeder A, Hsieh SC, Liberto JM, Damm I, Geraedts ACM, Sarwal MM| | PubMed
  29. A Modified Injector and Sample Acquisition Protocol Can Improve Data Quality and Reduce Inter-Instrument Variability of the Helios Mass Cytometer.
    Lee BH, Kelly G, Bradford S, Davila M, Guo XV, Amir ED, Thrash EM, Solga MD, Lannigan J, Sellers B, Candia J, Tsang J, Montgomery RR, Tamaki SJ, Sigdel TK, Sarwal MM, Lanier LL, Tian Y, Kim C, Hinz D, Peters B, Sette A, Rahman AH| | PubMed
  30. Characterizing pre-transplant and post-transplant kidney rejection risk by B cell immune repertoire sequencing.
    Pineda S, Sigdel TK, Liberto JM, Vincenti F, Sirota M, Sarwal MM| | PubMed
  31. A Novel Multi-Biomarker Assay for Non-Invasive Quantitative Monitoring of Kidney Injury.
    Watson D, Yang JYC, Sarwal RD, Sigdel TK, Liberto JM, Damm I, Louie V, Sigdel S, Livingstone D, Soh K, Chakraborty A, Liang M, Lin PC, Sarwal MM| | PubMed
  32. Cell-Free DNA and CXCL10 Derived from Bronchoalveolar Lavage Predict Lung Transplant Survival.
    Yang JYC, Verleden SE, Zarinsefat A, Vanaudenaerde BM, Vos R, Verleden GM, Sarwal RD, Sigdel TK, Liberto JM, Damm I, Watson D, Sarwal MM| | PubMed
  33. Optimizing Detection of Kidney Transplant Injury by Assessment of Donor-Derived Cell-Free DNA via Massively Multiplex PCR.
    Sigdel TK, Archila FA, Constantin T, Prins SA, Liberto J, Damm I, Towfighi P, Navarro S, Kirkizlar E, Demko ZP, Ryan A, Sigurjonsson S, Sarwal RD, Hseish SC, Chan-On C, Zimmermann B, Billings PR, Moshkevich S, Sarwal MM| | PubMed
  34. The common rejection module in chronic rejection post lung transplantation.
    Sacreas A, Yang JYC, Vanaudenaerde BM, Sigdel TK, Liberto JM, Damm I, Verleden GM, Vos R, Verleden SE, Sarwal MM| | PubMed
  35. Urinary Virome Perturbations in Kidney Transplantation.
    Sigdel TK, Mercer N, Nandoe S, Nicora CD, Burnum-Johnson K, Qian WJ, Sarwal MM| | PubMed
  36. Targeted Transcriptional Profiling of Kidney Transplant Biopsies.
    Sigdel TK, Nguyen M, Dobi D, Hsieh SC, Liberto JM, Vincenti F, Sarwal MM, Laszik Z| | PubMed
  37. Corrigendum: Novel Non-Histocompatibility Antigen Mismatched Variants Improve the Ability to Predict Antibody-Mediated Rejection Risk in Kidney Transplant.
    Pineda S, Sigdel TK, Chen J, Jackson AM, Sirota M, Sarwal MM| | PubMed
  38. Discovery of Immune Reactive Human Proteins by High-Density Protein Arrays and Customized Validation of Potential Biomarkers by ELISA.
    Sigdel TK, Sarwal MM| | PubMed
  39. Fractionation of Soluble Proteins Using DEAE-Sepharose, SP-Sepharose, and Phenyl Sepharose Chromatographies for Proteomics.
    Towfighi P, Shaw J, Sigdel T| | PubMed
  40. LC-SRM-Based Targeted Quantification of Urinary Protein Biomarkers.
    Gao Y, Wang H, Nicora CD, Shi T, Smith RD, Sigdel TK, Sarwal MM, Camp DG, Qian WJ| | PubMed
  41. Optimization for Peptide Sample Preparation for Urine Peptidomics.
    Sigdel TK, Nicora CD, Qian WJ, Sarwal MM| | PubMed
  42. Novel Non-Histocompatibility Antigen Mismatched Variants Improve the Ability to Predict Antibody-Mediated Rejection Risk in Kidney Transplant.
    Pineda S, Sigdel TK, Chen J, Jackson AM, Sirota M, Sarwal MM| | PubMed
  43. Expression of Mitochondrial-Encoded Genes in Blood Differentiate Acute Renal Allograft Rejection.
    Roedder S, Sigdel T, Hsieh SC, Cheeseman J, Metes D, Macedo C, Reed EF, Gritsch HA, Zeevi A, Shapiro R, Kirk AD, Sarwal MM| | PubMed
  44. Polyclonal Regulatory T Cell Therapy for Control of Inflammation in Kidney Transplants.
    Chandran S, Tang Q, Sarwal M, Laszik ZG, Putnam AL, Lee K, Leung J, Nguyen V, Sigdel T, Tavares EC, Yang JYC, Hellerstein M, Fitch M, Bluestone JA, Vincenti F| | PubMed
  45. Assessment of Circulating Protein Signatures for Kidney Transplantation in Pediatric Recipients.
    Sigdel TK, Sarwal MM| | PubMed
  46. Molecular and Functional Noninvasive Immune Monitoring in the ESCAPE Study for Prediction of Subclinical Renal Allograft Rejection.
    Crespo E, Roedder S, Sigdel T, Hsieh SC, Luque S, Cruzado JM, Tran TQ, Grinyó JM, Sarwal MM, Bestard O| | PubMed
  47. Prevalence and pattern of dyslipidemia in Nepalese individuals with type 2 diabetes.
    Pokharel DR, Khadka D, Sigdel M, Yadav NK, Acharya S, Kafle R, Sapkota RM, Sigdel T| | PubMed
  48. A combined biomarker and clinical panel for chronic graft versus host disease diagnosis.
    Pidala J, Sigdel TK, Wang A, Hsieh S, Inamoto Y, Martin PJ, Flowers ME, Hansen JA, Lee SJ, Sarwal MM| | PubMed
  49. Advances in diagnostics for transplant rejection.
    Nasr M, Sigdel T, Sarwal M| | PubMed
  50. Intragraft Antiviral-Specific Gene Expression as a Distinctive Transcriptional Signature for Studies in Polyomavirus-Associated Nephropathy.
    Sigdel TK, Bestard O, Salomonis N, Hsieh SC, Torras J, Naesens M, Tran TQ, Roedder S, Sarwal MM| | PubMed
  51. Self-antigens and rejection: a proteomic analysis.
    Yang JY, Sigdel TK, Sarwal MM| | PubMed
  52. Mining the human urine proteome for monitoring renal transplant injury.
    Sigdel TK, Gao Y, He J, Wang A, Nicora CD, Fillmore TL, Shi T, Webb-Robertson BJ, Smith RD, Qian WJ, Salvatierra O, Camp DG, Sarwal MM| | PubMed
  53. Circulating CD40 autoantibody and suPAR synergy drives glomerular injury.
    Wei C, Sigdel TK, Sarwal MM, Reiser J| | PubMed
  54. A Computational Gene Expression Score for Predicting Immune Injury in Renal Allografts.
    Sigdel TK, Bestard O, Tran TQ, Hsieh SC, Roedder S, Damm I, Vincenti F, Sarwal MM| | PubMed
  55. Transcriptional Perturbations in Graft Rejection.
    Vitalone MJ, Sigdel TK, Salomonis N, Sarwal RD, Hsieh SC, Sarwal MM| | PubMed
  56. Perturbations in the urinary exosome in transplant rejection.
    Sigdel TK, Ng YW, Lee S, Nicora CD, Qian WJ, Smith RD, Camp DG, Sarwal MM| | PubMed
  57. Mapping novel immunogenic epitopes in IgA nephropathy.
    Woo SH, Sigdel TK, Dinh VT, Vu MT, Sarwal MM, Lafayette RA| | PubMed
  58. A Three-Gene Assay for Monitoring Immune Quiescence in Kidney Transplantation.
    Roedder S, Li L, Alonso MN, Hsieh SC, Vu MT, Dai H, Sigdel TK, Bostock I, Macedo C, Metes D, Zeevi A, Shapiro R, Salvatierra O, Scandling J, Alberu J, Engleman E, Sarwal MM| | PubMed
  59. The kSORT assay to detect renal transplant patients at high risk for acute rejection: results of the multicenter AART study.
    Roedder S, Sigdel T, Salomonis N, Hsieh S, Dai H, Bestard O, Metes D, Zeevi A, Zeevi A, Gritsch A, Cheeseman J, Macedo C, Peddy R, Medeiros M, Vincenti F, Asher N, Salvatierra O, Shapiro R, Kirk A, Reed EF, Reed E, Sarwal MM| | PubMed
  60. Endothelial cell antibodies associated with novel targets and increased rejection.
    Jackson AM, Sigdel TK, Delville M, Hsieh SC, Dai H, Bagnasco S, Montgomery RA, Sarwal MM| | PubMed
  61. A circulating antibody panel for pretransplant prediction of FSGS recurrence after kidney transplantation.
    Delville M, Sigdel TK, Wei C, Li J, Hsieh SC, Fornoni A, Burke GW, Bruneval P, Naesens M, Jackson A, Alachkar N, Canaud G, Legendre C, Anglicheau D, Reiser J, Sarwal MM| | PubMed
  62. Optimization for peptide sample preparation for urine peptidomics.
    Sigdel TK, Nicora CD, Hsieh SC, Dai H, Qian WJ, Camp DG, Sarwal MM| | PubMed
  63. Identification of common blood gene signatures for the diagnosis of renal and cardiac acute allograft rejection.
    Li L, Khush K, Hsieh SC, Ying L, Luikart H, Sigdel T, Roedder S, Yang A, Valantine H, Sarwal MM| | PubMed
  64. The identification of novel potential injury mechanisms and candidate biomarkers in renal allograft rejection by quantitative proteomics.
    Sigdel TK, Salomonis N, Nicora CD, Ryu S, He J, Dinh V, Orton DJ, Moore RJ, Hsieh SC, Dai H, Thien-Vu M, Xiao W, Smith RD, Qian WJ, Camp DG, Sarwal MM| | PubMed
  65. Moving beyond HLA: a review of nHLA antibodies in organ transplantation.
    Sigdel TK, Sarwal MM| | PubMed
  66. A rapid noninvasive assay for the detection of renal transplant injury.
    Sigdel TK, Vitalone MJ, Tran TQ, Dai H, Hsieh SC, Salvatierra O, Sarwal MM| | PubMed
  67. Multicenter evaluation of a standardized protocol for noninvasive gene expression profiling.
    Keslar KS, Lin M, Zmijewska AA, Sigdel TK, Tran TQ, Ma L, Bhasin M, Rao P, Ding R, Iklé DN, Mannon RB, Sarwal MM, Strom TB, Reed EF, Heeger PS, Suthanthiran M, Fairchild RL| | PubMed
  68. Immune response profiling identifies autoantibodies specific to Moyamoya patients.
    Sigdel TK, Shoemaker LD, Chen R, Li L, Butte AJ, Sarwal MM, Steinberg GK| | PubMed
  69. The clinical impact of humoral immunity in pediatric renal transplantation.
    Chaudhuri A, Ozawa M, Everly MJ, Ettenger R, Dharnidharka V, Benfield M, Mathias R, Portale A, McDonald R, Harmon W, Kershaw D, Vehaskari VM, Kamil E, Baluarte HJ, Warady B, Li L, Sigdel TK, Hsieh SC, Dai H, Naesens M, Waskerwitz J, Salvatierra O, Terasaki PI, Sarwal MM| | PubMed
  70. A common blood gene assay predates clinical and histological rejection in kidney and heart allografts.
    Sarwal M, Sigdel T| | PubMed
  71. Discovery and customized validation of antibody targets by protein arrays and indirect ELISA.
    Sigdel TK, Sarwal MM| | PubMed
  72. A peripheral blood diagnostic test for acute rejection in renal transplantation.
    Li L, Khatri P, Sigdel TK, Tran T, Ying L, Vitalone MJ, Chen A, Hsieh S, Dai H, Zhang M, Naesens M, Zarkhin V, Sansanwal P, Chen R, Mindrinos M, Xiao W, Benfield M, Ettenger RB, Dharnidharka V, Mathias R, Portale A, McDonald R, Harmon W, Kershaw D, Vehaskari VM, Kamil E, Baluarte HJ, Warady B, Davis R, Butte AJ, Salvatierra O, Sarwal MM| | PubMed
  73. Complete steroid avoidance is effective and safe in children with renal transplants: a multicenter randomized trial with three-year follow-up.
    Sarwal MM, Ettenger RB, Dharnidharka V, Benfield M, Mathias R, Portale A, McDonald R, Harmon W, Kershaw D, Vehaskari VM, Kamil E, Baluarte HJ, Warady B, Tang L, Liu J, Li L, Naesens M, Sigdel T, Waskerwitz J, Salvatierra O| | PubMed
  74. Protein and peptide biomarkers in organ transplantation.
    Sigdel TK, Gao X, Sarwal MM| | PubMed
  75. Non-HLA antibodies to immunogenic epitopes predict the evolution of chronic renal allograft injury.
    Sigdel TK, Li L, Tran TQ, Khatri P, Naesens M, Sansanwal P, Dai H, Hsieh SC, Sarwal MM| | PubMed
  76. Cell-free DNA as a measure of transplant injury.
    Sigdel TK, Sarwal MM| | PubMed
  77. Characterization of Zn(II)-responsive ribosomal proteins YkgM and L31 in E. coli.
    Hensley MP, Gunasekera TS, Easton JA, Sigdel TK, Sugarbaker SA, Klingbeil L, Breece RM, Tierney DL, Crowder MW| | PubMed
  78. Profiling of autoantibodies in IgA nephropathy, an integrative antibiomics approach.
    Sigdel TK, Woo SH, Dai H, Khatri P, Li L, Myers B, Sarwal MM, Lafayette RA| | PubMed
  79. Recent advances in biomarker discovery in solid organ transplant by proteomics.
    Sigdel TK, Sarwal MM| | PubMed
  80. The dual role of epithelial-to-mesenchymal transition in chronic allograft injury in pediatric renal transplantation.
    Vitalone MJ, Naesens M, Sigdel T, Li L, Hseih S, Sarwal MM| | PubMed
  81. Functional proteogenomics--embracing complexity.
    Sarwal MM, Sigdel TK, Salomon DR| | PubMed
  82. Progressive histological damage in renal allografts is associated with expression of innate and adaptive immunity genes.
    Naesens M, Khatri P, Li L, Sigdel TK, Vitalone MJ, Chen R, Butte AJ, Salvatierra O, Sarwal MM| | PubMed
  83. Profiling the proteome in renal transplantation.
    Sigdel TK, Lee S, Sarwal MM| | PubMed
  84. Protein microarrays discover angiotensinogen and PRKRIP1 as novel targets for autoantibodies in chronic renal disease.
    Butte AJ, Sigdel TK, Wadia PP, Miklos DB, Sarwal MM| | PubMed
  85. Differential immunogenicity and clinical relevance of kidney compartment specific antigens after renal transplantation.
    Li L, Sigdel T, Vitalone M, Lee SH, Sarwal M| | PubMed
  86. Differentially expressed RNA from public microarray data identifies serum protein biomarkers for cross-organ transplant rejection and other conditions.
    Chen R, Sigdel TK, Li L, Kambham N, Dudley JT, Hsieh SC, Klassen RB, Chen A, Caohuu T, Morgan AA, Valantine HA, Khush KK, Sarwal MM, Butte AJ| | PubMed
  87. Compartmental localization and clinical relevance of MICA antibodies after renal transplantation.
    Li L, Chen A, Chaudhuri A, Kambham N, Sigdel T, Chen R, Sarwal MM| | PubMed
  88. Integrative urinary peptidomics in renal transplantation identifies biomarkers for acute rejection.
    Ling XB, Sigdel TK, Lau K, Ying L, Lau I, Schilling J, Sarwal MM| | PubMed
  89. Shotgun proteomics identifies proteins specific for acute renal transplant rejection.
    Sigdel TK, Kaushal A, Gritsenko M, Norbeck AD, Qian WJ, Xiao W, Camp DG, Smith RD, Sarwal MM| | PubMed
  90. Protein microarrays identify antibodies to protein kinase Czeta that are associated with a greater risk of allograft loss in pediatric renal transplant recipients.
    Sutherland SM, Li L, Sigdel TK, Wadia PP, Miklos DB, Butte AJ, Sarwal MM| | PubMed
  91. Expression of complement components differs between kidney allografts from living and deceased donors.
    Naesens M, Li L, Ying L, Sansanwal P, Sigdel TK, Hsieh SC, Kambham N, Lerut E, Salvatierra O, Butte AJ, Sarwal MM| | PubMed
  92. Identifying compartment-specific non-HLA targets after renal transplantation by integrating transcriptome and "antibodyome" measures.
    Li L, Wadia P, Chen R, Kambham N, Naesens M, Sigdel TK, Miklos DB, Sarwal MM, Butte AJ| | PubMed
  93. Interpreting the proteome and peptidome in transplantation.
    Sigdel TK, Klassen RB, Sarwal MM| | PubMed
  94. A randomized, prospective trial of rituximab for acute rejection in pediatric renal transplantation.
    Zarkhin V, Li L, Kambham N, Sigdel T, Salvatierra O, Sarwal MM| | PubMed
  95. The proteogenomic path towards biomarker discovery.
    Sigdel TK, Sarwal MM| | PubMed
  96. Optimizing protein recovery for urinary proteomics, a tool to monitor renal transplantation.
    Sigdel TK, Lau K, Schilling J, Sarwal M| | PubMed
  97. Interference of globin genes with biomarker discovery for allograft rejection in peripheral blood samples.
    Li L, Ying L, Naesens M, Xiao W, Sigdel T, Hsieh S, Martin J, Chen R, Liu K, Mindrinos M, Davis R, Sarwal M| | PubMed
  98. Probing the adaptive response of Escherichia coli to extracellular Zn(II).
    Sigdel TK, Cilliers R, Gursahaney PR, Thompson P, Easton JA, Crowder MW| | PubMed
  99. Transcriptional response of Escherichia coli to TPEN.
    Sigdel TK, Easton JA, Crowder MW| | PubMed
  100. Phosphinate, sulfonate, and sulfonamidate dipeptides as potential inhibitors of Escherichia coli aminopeptidase N.
    Yang KW, Golich FC, Sigdel TK, Crowder MW| | PubMed
  101. A five-coordinate metal center in Co(II)-substituted VanX.
    Breece RM, Costello A, Bennett B, Sigdel TK, Matthews ML, Tierney DL, Crowder MW| | PubMed
  102. Fractionation of soluble proteins in Escherichia coli using DEAE-, SP-, and phenyl sepharose chromatographies.
    Sigdel TK, Cilliers R, Gursahaney PR, Crowder MW| | PubMed
  103. L-alanine-p-nitroanilide is not a substrate for VanX.
    Golich FC, Sigdel T, Breece RM, Detar L, Herron LR, Crowder MW| | PubMed
  104. Over-expression, purification, and characterization of metallo-beta-lactamase ImiS from Aeromonas veronii bv. sobria.
    Crawford PA, Sharma N, Chandrasekar S, Sigdel T, Walsh TR, Spencer J, Crowder MW| | PubMed
  105. In vivo folding of recombinant metallo-beta-lactamase L1 requires the presence of Zn(II).
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