University of California San Francisco

Paul Brakeman - 144
Paul
Brakeman
MD, PhD

Associate Clinical Professor of Pediatrics
Medical Director, Pediatric Dialysis Unit
Division of Pediatric Nephrology
Department of Pediatrics

Address

550 16th Street, #4355
San Francisco, CA 94158
United States

Email: [email protected]
Fax: 415-476-9976

Biography

Dr. Brakeman is an Associate Professor based at the UCSF Benioff Children's Hospital with a primary appointment in Pediatrics and a secondary appointment in the Division of Nephrology in the Department of Medicine. He completed his undergraduate training at UC Berkeley in biophysics before entering a combined MD/PhD program at the Johns Hopkins University School of Medicine. His thesis work consisted of evaluating the role of immediate early genes in learning and memory during brain development. He completed his MD and PhD degrees in 1997 before coming to UCSF to pursue residency in the Department of Pediatrics. Dr. Brakeman served as chief resident in pediatrics in 2000-2001 and then went on to become a fellow in the Division of Pediatric Nephrology at UCSF. During his fellowship, Dr. Brakeman began his renal research career, studying kidney development and the molecular mechanisms of kidney morphogenesis. Dr. Brakeman joined the UCSF faculty after completing his fellowship in 2004.

Since joining the UCSF faculty, Dr. Brakeman has developed clinical expertise in the evaluation and treatment of pediatric dialysis patients, pediatric chronic kidney disease, urinary tract infections and obstructive nephropathy. 

Education

Institution Degree Dept or School End Date
John Hopkins University M.D. School of Medicine 1997
University of California, San Francisco Residency School of Medicine

Board Certifications

American Board of Pediatrics - General Pediatrics
American Board of Pediatrics - Pediatric Nephrology Subspecialty

Awards & Honors

Award Conferred By Date
Top Doctor Marin Magazine 2019
Top Doctor San Francisco Magazine 2019
Designated Nephrotic Syndrome Expert Nephcure Kidney International 2018
Excellence in Teaching Award Haile T. Debas Academy of Medical Educators 2016

Clinical Expertise

Chronic kidney disease
Obstructive nephropathy
Pediatric dialysis
Systemic lupus erythematous
Urinary tract infection

In the News

East Bay Toddler in Waiting Game For a Combined Liver-Kidney Transplant at UCSF
November, 24, 2012 | UCSF Transplant Surgery

Grants and Funding

  • The Role of Nectin in Congenital Obstructive Nephropathy | NIH | 2004-09-01 - 2010-11-30 | Role: Principal Investigator

Research Narrative

The primary focus of Dr. Brakeman's research is the engineering of human renal epithelial cells for use in a bioartificial kidney. Work is currently underway at UCSF on a multi-center project to develop a bioartificial implantable renal assist device based on hemofiltration. One of the important components of an implantable bioartificial device is an active renal proximal tubule cell bioreactor that can provide some of the metabolic activity of renal tubules. Another critical function of the cellular bioreactor will be the reabsorption of salt and water in order to reduce the volume of the filtrate generated as much as possible before elimination via the bladder. Dr. Brakeman's lab is focused on engineering human proximal tubules cells to enhance sodium and water reabsorption for use in the bioartificial kidney. In addition, he is actively evaluating the use of the proximal tubule cell bioreactor for use in toxicology and pharmaceutical evaluation of novel compounds. 

Dr. Brakeman's work is funded by the Roger's Family Foundation.

Research Interests

Kidney development
Artificial kidney engineering
Sodium and water transport

Publications

MOST RECENT PUBLICATIONS FROM A TOTAL OF 44
  1. Nectin proteins are expressed at early stages of nephrogenesis and play a role in renal epithelial cell morphogenesis.
    Brakeman PR, Liu KD, Shimizu K, Takai Y, Mostov KE| | PubMed
  2. Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarity.
    Yu W, Shewan AM, Brakeman P, Eastburn DJ, Datta A, Bryant DM, Fan QW, Weiss WA, Zegers MM, Mostov KE| | PubMed
  3. Renal repair and recovery.
    Liu KD, Brakeman PR| | PubMed
  4. Transient hyperglycemia affects the extent of ischemia-reperfusion-induced renal injury in rats.
    Hirose R, Xu F, Dang K, Liu T, Behrends M, Brakeman PR, Wiener-Kronish J, Niemann CU| | PubMed
  5. Being overweight modifies the association between cardiovascular risk factors and microalbuminuria in adolescents.
    Nguyen S, McCulloch C, Brakeman P, Portale A, Hsu CY| | PubMed
  6. Vesicoureteral reflux, reflux nephropathy, and end-stage renal disease.
    Brakeman P| | PubMed
  7. Rac1 is required for reorientation of polarity and lumen formation through a PI 3-kinase-dependent pathway.
    Liu KD, Datta A, Yu W, Brakeman PR, Jou TS, Matthay MA, Mostov KE| | PubMed
  8. Polarity proteins PAR6 and aPKC regulate cell death through GSK-3beta in 3D epithelial morphogenesis.
    Kim M, Datta A, Brakeman P, Yu W, Mostov KE| | PubMed
  9. Formation of multicellular epithelial structures.
    Mostov K, Brakeman P, Datta A, Gassama A, Katz L, Kim M, Leroy P, Levin M, Liu K, Martin F, O'Brien LE, Verges M, Su T, Tang K, Tanimizu N, Yamaji T, Yu W| | PubMed
  10. The scaffold protein, Homer1b/c, regulates axon pathfinding in the central nervous system in vivo.
    Foa L, Rajan I, Haas K, Wu GY, Brakeman P, Worley P, Cline H| | PubMed
44
View all 44 Publications
MOST RECENT PUBLICATIONS FROM A TOTAL OF 44
  1. Voices of Hope: Leveraging Think-Aloud Cognitive Interviews to Develop a Hope Assessment Tool for Young People Living with Chronic Health Conditions.
    von Scheven E, Braun M, Nahal B, Perito ER, Brakeman P, Soulsby WD, Quill L, Cuneo A, Franck LS| | PubMed
  2. Healthcare Utilization Among Youth with Chronic Illness Receiving Care at a Large Urban Academic Healthcare System.
    Soulsby WD, Franck LS, Perito E, Brakeman P, Cuneo A, Quill L, Boscardin J, von Scheven E| | PubMed
  3. Feasibility of an implantable bioreactor for renal cell therapy using silicon nanopore membranes.
    Kim EJ, Chen C, Gologorsky R, Santandreu A, Torres A, Wright N, Goodin MS, Moyer J, Chui BW, Blaha C, Brakeman P, Vartanian S, Tang Q, David Humes H, Fissell WH, Roy S| | PubMed
  4. Persistent Increase in Serum Ferritin Levels despite Converting to Permanent Vascular Access in Pediatric Hemodialysis Patients: Pediatric Nephrology Research Consortium Study.
    Onder AM, Ansari MAY, Deng F, Grinsell MM, Patterson L, Jetton J, Fathallah-Shaykh S, Ranch D, Aviles D, Copelovitch L, Ellis E, Chadha V, Elmaghrabi A, Lin JJ, Butani L, Haddad M, Marsenic O, Brakeman P, Quigley R, Shin HS, Garro R, Raina R, Langman CB| | PubMed
  5. COVID-19 in pediatric kidney transplantation: a follow-up report of the Improving Renal Outcomes Collaborative.
    Varnell C, Harshman LA, Liu C, Smith L, Al-Akash S, Barletta GM, Brakeman P, Chaudhuri A, Fadakar P, Galea L, Garro R, Gluck C, Kershaw DB, Matossian D, Patel HP, Peterson C, Pruette C, Ranabothu S, Rodig N, Singer P, Sebestyen VanSickle J, Weng PL, Danziger-Isakov L, Seifert ME, Hooper DK| | PubMed
  6. Urologic Considerations in Pediatric Chronic Kidney Disease.
    Lombel RM, Brakeman PR, Sack BS, Butani L| | PubMed
  7. Conversion to permanent vascular access is associated with improved markers of hemodialysis efficacy in children: Pediatric nephrology research consortium study.
    Onder AM, Flynn JT, Ansari MAY, Deng F, DeFreitas M, Katsoufis C, Grinsell MM, Patterson L, Jetton J, Fathallah-Shaykh S, Ranch D, Aviles D, Copelovitch L, Ellis E, Chadha V, Elmaghrabi A, Lin JJ, Butani L, Haddad M, Marsenic O, Brakeman P, Quigley R, Shin HS, Garro R, Raina R, Langman CB, Wood E, Pediatric Nephrology Research Consortium| | PubMed
  8. Association of Plasma Uremic Solute Levels with Residual Kidney Function in Children on Peritoneal Dialysis.
    Ganesan LL, O'Brien FJ, Sirich TL, Plummer NS, Sheth R, Fajardo C, Brakeman P, Sutherland SM, Meyer TW| | PubMed
  9. COVID-19 in pediatric kidney transplantation: The Improving Renal Outcomes Collaborative.
    Varnell C, Harshman LA, Smith L, Liu C, Chen S, Al-Akash S, Barletta GM, Belsha C, Brakeman P, Chaudhuri A, Fadakar P, Garro R, Gluck C, Goebel J, Kershaw D, Matossian D, Nailescu C, Patel HP, Pruette C, Ranabothu S, Rodig N, Smith J, Sebestyen VanSickle J, Weng P, Danziger-Isakov L, Hooper DK, Seifert M| | PubMed
  10. Plasma pseudouridine levels reflect body size in children on hemodialysis.
    O'Brien FJ, Sirich TL, Taussig A, Fung E, Ganesan LL, Plummer NS, Brakeman P, Sutherland SM, Meyer TW| | PubMed
  11. Predictors of time to first cannulation for arteriovenous fistula in pediatric hemodialysis patients: Midwest Pediatric Nephrology Consortium study.
    Onder AM, Flynn JT, Billings AA, Deng F, DeFreitas M, Katsoufis C, Grinsell MM, Patterson L, Jetton J, Fathallah-Shaykh S, Ranch D, Aviles D, Copelovitch L, Ellis E, Chadha V, Elmaghrabi A, Lin JJ, Butani L, Haddad M, Marsenic O, Brakeman P, Quigley R, Shin HS, Garro R, Liu H, Rahimikollu J, Raina R, Langman CB, Wood E, Midwest Pediatric Nephrology Consortium| | PubMed
  12. Simple Rules Determine Distinct Patterns of Branching Morphogenesis.
    Yu W, Marshall WF, Metzger RJ, Brakeman PR, Morsut L, Lim W, Mostov KE| | PubMed
  13. Correction to: Predictors of patency for arteriovenous fistulae and grafts in pediatric hemodialysis patients.
    Onder AM, Flynn JT, Billings AA, Deng F, DeFreitas M, Katsoufis C, Grinsell MM, Patterson LT, Jetton J, Fathallah-Shaykh S, Ranch D, Aviles D, Copelovitch L, Ellis E, Chadha V, Elmaghrabi A, Lin JJ, Butani L, Haddad M, Couloures OM, Brakeman P, Quigley R, Shin HS, Garro R, Liu H, Rahimikollu J, Raina R, Langman CB, Wood EG, Midwest Pediatric Nephrology Consortium| | PubMed
  14. Application of physiological shear stress to renal tubular epithelial cells.
    Ferrell N, Sandoval RM, Molitoris BA, Brakeman P, Roy S, Fissell WH| | PubMed
  15. Positive Cumulative Fluid Balance Is Associated With Mortality in Pediatric Acute Respiratory Distress Syndrome in the Setting of Acute Kidney Injury.
    Zinter MS, Spicer AC, Liu KD, Orwoll BE, Alkhouli MF, Brakeman PR, Calfee CS, Matthay MA, Sapru A| | PubMed
  16. Apical Shear Stress Enhanced Organic Cation Transport in Human OCT2/MATE1-Transfected Madin-Darby Canine Kidney Cells Involves Ciliary Sensing.
    Jayagopal A, Brakeman PR, Soler P, Ferrell N, Fissell W, Kroetz DL, Roy S| | PubMed
  17. Outcome of participants with nephrotic syndrome in combined clinical trials of lupus nephritis.
    Gomez Mendez LM, Cascino MD, Katsumoto TR, Brakeman P, Brunetta P, Jayne D, Dall'Era M, Rovin B, Garg J| | PubMed
  18. Predictors of patency for arteriovenous fistulae and grafts in pediatric hemodialysis patients.
    Onder AM, Flynn JT, Billings AA, Deng F, DeFreitas M, Katsoufis C, Grinsell MM, Patterson LT, Jetton J, Fathallah-Shaykh S, Ranch D, Aviles D, Copelovitch L, Ellis E, Chanda V, Elmaghrabi A, Lin JJ, Butani L, Haddad M, Couloures OM, Brakeman P, Quigley R, Stella Shin H, Garro R, Liu H, Rahimikollu J, Raina R, Langman CB, Wood EG, Midwest Pediatric Nephrology Consortium| | PubMed
  19. Peripheral Blood B Cell Depletion after Rituximab and Complete Response in Lupus Nephritis.
    Gomez Mendez LM, Cascino MD, Garg J, Katsumoto TR, Brakeman P, Dall'Era M, Looney RJ, Rovin B, Dragone L, Brunetta P| | PubMed
  20. Renal function outcomes in pediatric patients with symptomatic reflux into the transplanted kidney treated with redo ureteroneocystostomy.
    Wang MK, Chuang KW, Li Y, Gaither T, Brakeman P, Gonzalez L, Brennan J, Baskin LS| | PubMed
  21. Afadin orients cell division to position the tubule lumen in developing renal tubules.
    Gao L, Yang Z, Hiremath C, Zimmerman SE, Long B, Brakeman PR, Mostov KE, Bryant DM, Luby-Phelps K, Marciano DK| | PubMed
  22. Laser acupuncture reduces pain in pediatric kidney biopsies: a randomized controlled trial.
    Oates A, Benedict KA, Sun K, Brakeman PR, Lim J, Kim C| | PubMed
  23. A modular microfluidic bioreactor with improved throughput for evaluation of polarized renal epithelial cells.
    Brakeman P, Miao S, Cheng J, Lee CZ, Roy S, Fissell WH, Ferrell N| | PubMed
  24. Preliminary Diffusive Clearance of Silicon Nanopore Membranes in a Parallel Plate Configuration for Renal Replacement Therapy.
    Kim S, Heller J, Iqbal Z, Kant R, Kim EJ, Durack J, Saeed M, Do L, Hetts S, Wilson M, Brakeman P, Fissell WH, Roy S| | PubMed
  25. Host cell polarity proteins participate in innate immunity to Pseudomonas aeruginosa infection.
    Tran CS, Eran Y, Ruch TR, Bryant DM, Datta A, Brakeman P, Kierbel A, Wittmann T, Metzger RJ, Mostov KE, Engel JN| | PubMed
  26. Acute changes in blood pressure in patients with neuroblastoma treated with ¹³¹I-metaiodobenzylguanidine (MIBG).
    Wong T, Matthay KK, Boscardin WJ, Hawkins RA, Brakeman PR, DuBois SG| | PubMed
  27. De novo lumen formation and elongation in the developing nephron: a central role for afadin in apical polarity.
    Yang Z, Zimmerman S, Brakeman PR, Beaudoin GM, Reichardt LF, Marciano DK| | PubMed
  28. Synaptotagmin-like proteins control the formation of a single apical membrane domain in epithelial cells.
    Gálvez-Santisteban M, Rodriguez-Fraticelli AE, Bryant DM, Vergarajauregui S, Yasuda T, Bañón-Rodríguez I, Bernascone I, Datta A, Spivak N, Young K, Slim CL, Brakeman PR, Fukuda M, Mostov KE, Martín-Belmonte F| | PubMed
  29. Preso1 dynamically regulates group I metabotropic glutamate receptors.
    Hu JH, Yang L, Kammermeier PJ, Moore CG, Brakeman PR, Tu J, Yu S, Petralia RS, Li Z, Zhang PW, Park JM, Dong X, Xiao B, Worley PF| | PubMed
  30. p120 catenin is required for normal renal tubulogenesis and glomerulogenesis.
    Marciano DK, Brakeman PR, Lee CZ, Spivak N, Eastburn DJ, Bryant DM, Beaudoin GM, Hofmann I, Mostov KE, Reichardt LF| | PubMed
  31. Nectin proteins are expressed at early stages of nephrogenesis and play a role in renal epithelial cell morphogenesis.
    Brakeman PR, Liu KD, Shimizu K, Takai Y, Mostov KE| | PubMed
  32. Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarity.
    Yu W, Shewan AM, Brakeman P, Eastburn DJ, Datta A, Bryant DM, Fan QW, Weiss WA, Zegers MM, Mostov KE| | PubMed
  33. Renal repair and recovery.
    Liu KD, Brakeman PR| | PubMed
  34. Transient hyperglycemia affects the extent of ischemia-reperfusion-induced renal injury in rats.
    Hirose R, Xu F, Dang K, Liu T, Behrends M, Brakeman PR, Wiener-Kronish J, Niemann CU| | PubMed
  35. Being overweight modifies the association between cardiovascular risk factors and microalbuminuria in adolescents.
    Nguyen S, McCulloch C, Brakeman P, Portale A, Hsu CY| | PubMed
  36. Vesicoureteral reflux, reflux nephropathy, and end-stage renal disease.
    Brakeman P| | PubMed
  37. Rac1 is required for reorientation of polarity and lumen formation through a PI 3-kinase-dependent pathway.
    Liu KD, Datta A, Yu W, Brakeman PR, Jou TS, Matthay MA, Mostov KE| | PubMed
  38. Polarity proteins PAR6 and aPKC regulate cell death through GSK-3beta in 3D epithelial morphogenesis.
    Kim M, Datta A, Brakeman P, Yu W, Mostov KE| | PubMed
  39. Formation of multicellular epithelial structures.
    Mostov K, Brakeman P, Datta A, Gassama A, Katz L, Kim M, Leroy P, Levin M, Liu K, Martin F, O'Brien LE, Verges M, Su T, Tang K, Tanimizu N, Yamaji T, Yu W| | PubMed
  40. The scaffold protein, Homer1b/c, regulates axon pathfinding in the central nervous system in vivo.
    Foa L, Rajan I, Haas K, Wu GY, Brakeman P, Worley P, Cline H| | PubMed
  41. Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins.
    Tu JC, Xiao B, Naisbitt S, Yuan JP, Petralia RS, Brakeman P, Doan A, Aakalu VK, Lanahan AA, Sheng M, Worley PF| | PubMed
  42. Homer: a protein that selectively binds metabotropic glutamate receptors.
    Brakeman PR, Lanahan AA, O'Brien R, Roche K, Barnes CA, Huganir RL, Worley PF| | PubMed
  43. MR-based correction of brain PET measurements for heterogeneous gray matter radioactivity distribution.
    Meltzer CC, Zubieta JK, Links JM, Brakeman P, Stumpf MJ, Frost JJ| | PubMed
  44. Magnetohydrodynamics of blood flow.
    Keltner JR, Roos MS, Brakeman PR, Budinger TF| | PubMed