University of California San Francisco

Chris Hsiung Headshot
Chris
Hsiung
MD, PhD

Assistant Professor of Surgery
Division of Transplant Surgery

Address

513 Parnassus Avenue, HSE, #901F
San Francisco, CA 94143
United States

Biography

Dr. Chris Hsiung is a molecular geneticist and synthetic biologist who enjoys pondering and tinkering with the flow of genetic information in biological systems for fundamental understanding and therapeutic applications. Current research themes in the Hsiung Lab include: 1) understanding and engineering cell type-specific transcription, cell differentiation and epigenetic memory, 2) developing efficient approaches to exploring numerous combinatorial genetic perturbations, 3) applying functional genomics approaches to understand and engineer emergent properties of tissues, including tissue responses to injury and immune recognition of cancer."

Publications

MOST RECENT PUBLICATIONS FROM A TOTAL OF 12
  1. Engineered CRISPR-Cas12a for higher-order combinatorial chromatin perturbations.
    Hsiung CC, Wilson CM, Sambold NA, Dai R, Chen Q, Teyssier N, Misiukiewicz S, Arab A, O'Loughlin T, Cofsky JC, Shi J, Gilbert LA| | PubMed
  2. Higher-order combinatorial chromatin perturbations by engineered CRISPR-Cas12a for functional genomics.
    Hsiung CC, Wilson CM, Sambold NA, Dai R, Chen Q, Misiukiewicz S, Arab A, Teyssier N, O'Loughlin T, Cofsky JC, Shi J, Gilbert LA| | PubMed
  3. Effects of sheared chromatin length on ChIP-seq quality and sensitivity.
    Keller CA, Wixom AQ, Heuston EF, Giardine B, Hsiung CC, Long MR, Miller A, Anderson SM, Cockburn A, Blobel GA, Bodine DM, Hardison RC| | PubMed
  4. Interrogating Histone Acetylation and BRD4 as Mitotic Bookmarks of Transcription.
    Behera V, Stonestrom AJ, Hamagami N, Hsiung CC, Keller CA, Giardine B, Sidoli S, Yuan ZF, Bhanu NV, Werner MT, Wang H, Garcia BA, Hardison RC, Blobel GA| | PubMed
  5. A new bookmark of the mitotic genome in embryonic stem cells.
    Hsiung CC, Blobel GA| | PubMed
  6. A hyperactive transcriptional state marks genome reactivation at the mitosis-G1 transition.
    Hsiung CC, Bartman CR, Huang P, Ginart P, Stonestrom AJ, Keller CA, Face C, Jahn KS, Evans P, Sankaranarayanan L, Giardine B, Hardison RC, Raj A, Blobel GA| | PubMed
  7. Enhancer Regulation of Transcriptional Bursting Parameters Revealed by Forced Chromatin Looping.
    Bartman CR, Hsu SC, Hsiung CC, Raj A, Blobel GA| | PubMed
  8. Dynamic enhancer-gene body contacts during transcription elongation.
    Lee K, Hsiung CC, Huang P, Raj A, Blobel GA| | PubMed
  9. Genome accessibility is widely preserved and locally modulated during mitosis.
    Hsiung CC, Morrissey CS, Udugama M, Frank CL, Keller CA, Baek S, Giardine B, Crawford GE, Sung MH, Hardison RC, Blobel GA| | PubMed
  10. Comparative analysis of mitosis-specific antibodies for bulk purification of mitotic populations by fluorescence-activated cell sorting.
    Campbell AE, Hsiung CC, Blobel GA| | PubMed
  11. Native cysteine residues are dispensable for the structure and function of all five yeast mitotic septins.
    de Val N, McMurray MA, Lam LH, Hsiung CC, Bertin A, Nogales E, Thorner J| | PubMed
  12. Studies on adenovirus pneumonia in infants and young children.
    Chu FT, Chow HK, Chang IC, Liu HY, Wang HY, Hsiung CC| | PubMed