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Claus U. Niemann, M.D.

Claus U. Niemann, M.D.

  • Professor of Anesthesia and Surgery
  • Department of Anesthesia & Perioperative Care
  • Department of Surgery
  • Co-Director, Ischemic Organ Injury Lab

Contact Information

University of California, San Francisco
500 Parnassus MUE 4th Floor
Box 0648
San Francisco, Ca 94143-0648
Tel: 415-502-2162
[email protected]
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Education

  • 1986-93, Ludwig-Maximilians University, Munich, Germany, M.D.

Residencies

  • 1993-94  Intern ;  City Hospital St. Georg,, University of Hamburg, Germany and Klinikum Grosshadern, Ludwig-Maximilians University, Munich, Germany
  • 1996-99, University of California, San Francisco, Resident, Anesthesia

Fellowships

  • 1999-01, University of California, San Francisco, Fellow, Liver Transplant Research

Postdoctoral Training

  • 1994-96, Department of Anesthesiology, Northwestern University, Chicago, Illinois, Fellow, Postdoctoral Research

Board Certifications

  • American Board of Anesthesiology

Program Affiliations

  • Department of Anesthesia and Perioperative Care
  • Department of Surgery, Division of Transplantation
  • UCSF Liver Center

Clinical Expertise

  • Kidney Transplantation
  • Liver Transplantation
  • Pancreas Transplantation

Research Interests

  • View Research Profile at UCSF Clinical & Translational Science Institute

  • Inflammatory response to injuryIschemia reperfusion injury
  • Intensive Insulin Therapy in Deceased Donors-to improve renal allograft function and transplanted allograft outcomes
  • Liver transplantation
  • Metabolomics
  • Organ donation
  • Renal and hepatic injury during surgery

Website Links

Biography

My group is interested in identifying why obese individuals are at greater risk of liver injury in the setting of trauma or surgery. My long-term goal is to understand the relationship between metabolic and immunologic processes in the liver. One potential link between these underlying mechanisms could be the peptide leptin, which can profoundly modify inflammatory and metabolic pathways. The goal of this research effort is to improve understanding of the impact of leptin on acute inflammatory cascade and metabolic response during hepatic ischemia-reperfusion. This will benefit patients by improving risk-stratification of candidates for hepatic surgery and possibly lead to preventive therapies for ischemia-reperfusion injury.

Research Overview

My group is interested in identifying why obese individuals are at greater risk of liver injury in the setting of trauma or surgery. My long-term goal is to understand the relationship between metabolic and immunologic processes in the liver. One potential link between these underlying mechanisms could be the peptide leptin, which can profoundly modify inflammatory and metabolic pathways. The goal of this research effort is to improve understanding of the impact of leptin on acute inflammatory cascade and metabolic response during hepatic ischemia-reperfusion. This will benefit patients by improving risk-stratification of candidates for hepatic surgery and possibly lead to preventive therapies for ischemia-reperfusion injury. 

Clinical Trials

Data provided by UCSF Profiles, powered by CTSI

Publications

MOST RECENT PUBLICATIONS FROM A TOTAL OF 120
Data provided by UCSF Profiles, powered by CTSI
  1. Galli AM, Kothari R, Adelmann D, Holm Z, Bokoch MP, De Gasperi A, Niemann CU, Kolodzie K. Lactate concentration at the end of liver transplant: Early predictor of graft function or just one piece of the puzzle? Clin Transplant. 2023 Jun 23; e15057. View in PubMed
  2. Rodriguez-Davalos MI, Lopez-Verdugo F, Kasahara M, Muiesan P, Reddy MS, Flores-Huidobro Martinez A, Xia Q, Hong JC, Niemann CU, Seda-Neto J, Miloh TA, Yi NJ, Mazariegos GV, Ng VL, Esquivel CO, Lerut J, Rela M, Pediatric Liver Transplantation Global Census Group. International Liver Transplantation Society Global Census: First Look at Pediatric Liver Transplantation Activity Around the World. Transplantation. 2023 Jun 08. View in PubMed
  3. Malinoski D, Saunders C, Swain S, Groat T, Wood PR, Reese J, Nelson R, Prinz J, Kishish K, Van De Walker C, Geraghty PJ, Broglio K, Niemann CU. Hypothermia or Machine Perfusion in Kidney Donors. N Engl J Med. 2023 02 02; 388(5):418-426. View in PubMed
  4. Pollok JM, Tinguely P, Berenguer M, Niemann CU, Raptis DA, Spiro M, ERAS4OLT.org collaborative. Enhanced recovery for liver transplantation: recommendations from the 2022 International Liver Transplantation Society consensus conference. Lancet Gastroenterol Hepatol. 2023 01; 8(1):81-94. View in PubMed
  5. Holm ZD, Kolodzie K, Galli AM, Meyhoff CS, Niemann CU, Adelmann D. Perioperative mortality in liver transplantation before and after the implementation of the organ allocation policy Share 35. Clin Transplant. 2023 01; 37(1):e14854. View in PubMed
  6. View All Publications

In the News

  • Donor-Intervention Research Slowed Amidst Issues of Informed Consent and Conflicts Among Disparate IRBs

    UCSF Transplant Surgery - Richard Barg - August 16, 2017
    The Atlantic reports on the difficulties in the current climate of conducting donor-intervention research due to issues of informed consent, disagreements over what constitutes human subject research, and conflicting views of Institutional Review Boards (IRB) spread across multiple centers with patients putatively impacted by the research protocol. Moreover, doctors must test the experimental interventions designed to improve outcomes within the crucible of a short time window, given that a [...]

  • UCSF Research Team Shows that Mild Hypothermia in Deceased Organ Donors Improves Function in Kidney Transplant Recipients

    UCSF Transplant Surgery - Richard Barg - July 30, 2015
    UCSF News reports on a just published study in the The New England Journal of Medicine in which mild hypothermia in deceased organ donors was found to significantly reduce delayed graft function in kidney transplant recipients compared with normal body temperature. The lead author of the study is Claus Niemann, MD, Professor of Anesthesia and Surgery at UCSF, and co-Director of the Ischemic Organ Injury Lab. The findings in the study could lead to an increase in the availability of kidneys for [...]

  • UCSF Receives Grant to Improve Outcomes in Organ Donor Transplantation

    UCSF Transplant Surgery - October 20, 2011
    UCSF News reports on the award of a $2 million grant by the Health Resources and Services Administration (HRSA) to a team led by Claus Niemann, MD, Associate Professor in the UCSF Department of Anesthesia and Perioperative Care and co-Director of the Ischemic Organ Injury Lab to improve outcomes in organ donor transplantation.  The grant was awarded to Niemann and his collaborators including John Feiner, MD, as well as Ryutaro Hirose, MD, and John Roberts, MD, chief of the UCSF Transplant [...]

  • UCSF Liver Transplant Team Shares Expertise in Latin America

    UCSF Transplant Surgery - March 23, 2011
    Niemann
    "Previously, Uruguay had tried to go it alone, but high mortality rates soon caused doctors to shut the program down. After their initial visit, the UCSF transplant team, including anesthesiologist Claus U. Niemann, MD (pictured first), and surgeons Ryutaro Hirose, MD (pictured second), and Peter Stock, MD, PhD, (pictured third) continued to consult with the team in Uruguay, guiding them through everything from patient selection procedures to the use of immunosuppressive medications [...]

 

 
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